Associate Scientist – Lentiviral Vector Manufacture

Gene Therapy · Oxford, Oxfordshire
Department Gene Therapy
Employment Type Full-Time
Minimum Experience Entry-level
Compensation £20,000 - £28,000 per annum, dependent on experience plus benefits

The Associate Scientist – Lentiviral Vector Manufacture will work as part of an internal function for the generation and characterisation of viral vectors for both in-vitro and in-vivo applications (non-GMP). You will work with Scientist and Senior Scientist colleagues to expand this service within the company. This function sits within the Antibody & Viral Vector Manufacture Group, which addresses small scale (up to 200mL batches) and high-throughput production of lentiviral vectors, adeno-associated viral vectors (rAAVs) and adenoviral vectors.

 

You will work on commercial projects to deliver defined objectives, as well as on internal R&D projects to develop new technologies and platforms for future commercialisation. There will be frequent interactions and sometimes task sharing with Process Development group.


Key responsibilities:

  • With guidance and under supervision, contributing to the design and execution of experiments
  • Preparation of basic buffers, samples and reagents required for use in experiments
  • Providing experimental results analysis and project summaries
  • Presenting technical information, including analysis/results of experiments, to technical and non-technical audiences, both inside and outside the company
  • Supporting the writing of papers for publications through delivery of accurate and comprehensive data
  • Ensuring laboratory equipment is maintained in a good working condition
  • General housekeeping of laboratories
  • Maintaining laboratory cleanliness to OXGENE standards
  • Ensuring safe working practices in laboratory work areas
  • Communicating and co-ordinating activities with colleagues and management
  • Complying with the company’s Quality Management Systems


Qualifications, Skills and Experience:

Essential Criteria:

  • Minimum BSc in relevant discipline (Molecular Biology, Genetics or Cell Biology)
  • Demonstrable lab experience, ideally including mammalian cell culture techniques
  • Demonstrable molecular bilogy skills including PCR, RT-PCR and qRT-PCR
  • A high attention to detail
  • Excellent record-keeping skills
  • Ability to work in a laboratory under supervision and as part of a team on multiple projects, following established protocols, S.O.P.s and safety procedures
  • Good time management, communication, teamwork and numeracy skills


Desirable criteria:

  • Experience working in a commercial/industry environment is preferred but not essential
  • Handling and transfection of adherent cell lines in multiple formats (high throughput/multi-well plates, and hyperflasks/stacks)
  • Experience in production and characterisation of lentiviral vectors
  • Handling and transfection of suspension cell lines
  • Analytical techniques for genetic characterisation of viral particles such as IVCN (Integrated Vector Copy Number) qPCR


About OXGENE™

OXGENE, a WuXi Advanced Therapies (WuXI ATU) company, develops pioneering technologies to accelerate the discovery and biomanufacture of cell and gene therapies. We recruit only the best from across the globe to join us on our mission. We are focussed on providing our employees with a rich and rewarding work life, developing their skills sets and supporting their own personal aspirations. Our discovery technologies help pioneers advance their CAR-T, CRISPR, capsid or promoter discovery programmes. Our biomanufacturing solutions further accelerate the development and scalable manufacture of lentiviral, AAV or adenoviral vector based therapeutics.


OXGENE Benefits:

  • 25 days annual leave, increasing to 30 with service and 8 UK bank/public holidays per annual leave year and a day off on your birthday
  • Pension with salary exchange and generous employer contribution
  • Group life cover
  • Employee assistance programme
  • Private medical insurance with additional wellness benefits (as a benefit in kind)
  • Free tea, coffee, fruit-juice, fruit and biscuits, with kitchen facilities
  • Financially incentivised employee referral scheme


Notes to all applicants: 

To apply please visit our website and complete our application form with a copy of your CV. 

By the start of employment, the successful candidate must have, and be able to demonstrate, permission to work in the UK. Unfortunately, we are not currently able to provide sponsorship under the Skilled Worker route for candidates.


Closing Date

This advert will close as soon as sufficient applications have been received. Please submit your application as soon as possible to avoid missing the opportunity.

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  • Location
    Oxford, Oxfordshire
  • Department
    Gene Therapy
  • Employment Type
    Full-Time
  • Minimum Experience
    Entry-level
  • Compensation
    £20,000 - £28,000 per annum, dependent on experience plus benefits