Associate Scientist - Process Development

Gene Therapy · Oxford, Oxfordshire
Department Gene Therapy
Employment Type Full-Time
Minimum Experience Entry-level
Compensation £20,000 - £28,000 per annum, dependent on experience plus benefits

Duration: Permanent

Hours: Full-time Laboratory and Office based

Salary: £20,000 - £28,000 per annum, dependent on experience plus benefits

 

About OXGENE™

OXGENE redefines possible in mammalian cell engineering. Our technology platforms and expert solutions accelerate the discovery, development and manufacture of cell and gene therapies.

We address some of the most important and challenging questions in modern biology within gene therapy, antibody-based therapeutics and CRISPR / gene editing.

Our technologies enable precise and robust mammalian cell engineering. Our automation and informatics driven approaches mean we solve the problems that no-one else can to advance the delivery of new therapeutics.

 

Role Overview:

You will carry out a range of activities to support the Process Development group at OXGENE. The group incorporates Upstream (shake flask and bioreactor systems), Downstream (harvest/purification) and Analytical (titration and quality control) for both viral and protein therapeutics, with a particular focus on Lentivirus, adenovirus and adeno-associated virus (AAV).

 

The Associate Scientist will primarily focus on routine production and testing as well as process development for a novel viral platform with occasional exposure to other areas of process development through commercial and R&D projects. The role would also provide support for lab maintenance (cleaning and stock management), quality management (recording results and updating forms and SOPs), communication (summarising and presenting work). Depending on candidates background the role may be tailored more towards upstream or analytical operations.

 

This is an exciting opportunity to contribute to the successful expansion of the novel platform developed at OXGENE, and significant training and support in multiple areas of biological production and characterisation will be provided.

 

Key responsibilities:

  • Work closely with Scientist/ Senior Scientist colleagues to define objectives, and key support required for lab functions
  • Shake flask production of viral vectors (primarily adenovirus and AAV)
  • Titration and quality analysis of viral vector material
  • Prepare and execute process development and optimisation experiments for an internal platform.
  • Support other areas of Process Development as required with flexibility for additional training
  • Provide data summaries, accurate records and reports, as required
  • To adhere strictly to established quality standards, essential for on-going activities
  • Work within the team and contribute to smooth operations and communication.

 

Essential Criteria:

  • BSc or MSc in relevant scientific or engineering discipline (biology, chemistry, chemical engineering), with relevant laboratory experience (higher education qualifications with laboratory experience also considered)
  • Ability to work in a laboratory independently and as part of a team on multiple projects, following established protocols, SOPs and safety procedures.
  • Understanding of biological systems and production, preferably based on viral vector production
  • Practical experience of some or all techniques used in biopharmaceutical upstream processing and analysis (aseptic handling, mammalian cell culture (suspension and adherent), cell transfection, qPCR, ELISA, flow cytometry, microscopy)
  • Ability to write clear, professional and accurate reports in a timely fashion
  • Good time management, communication, teamwork and numeracy skills
  • Experience in the accurate and documented preparation of laboratory reagents
  • Experience in sample logging and tracking
  • Basic proficiency in MS office package. Intermediate or advanced proficiency advantageous

 

Desirable criteria:

  • Experience in handling viral vectors (Lentivirus, AAV and/or Adenovirus)
  • Experience working in a biopharmaceutical research or manufacturing environment
  • Advanced computing and/or data analysis skills (e.g. Design of Experiments, R, Advanced MS Excel skills, comparative statistics)
  • Experience operating bioreactors (especially using mammalian cells) may be an advantage
  • Experience working within controlled quality management system (e.g. ISO 9001, GxP)
  • Enthusiastic and ambitious approach to scientific research and biopharmaceutical production

 

Benefits 

  • Competitive Salary 
  • 25 days of annual leave, rising to 30 days with service and a day off on your birthday 
  • Free tea and coffee 
  • Cycle to work scheme 
  • Pension Scheme with up to 7% employer contribution
  • Private medical insurance as a benefit in kind
  • A friendly and flexible working environment 

 

Notes to all applicants 


All applicants must be eligible to work in the UK.

 

Correspondence may go into your junk/spam folders so please keep an eye on this. 

 

This advert will close as soon as sufficient applications have been received. Please submit your application as soon as possible to avoid missing the opportunity.

 

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  • Location
    Oxford, Oxfordshire
  • Department
    Gene Therapy
  • Employment Type
    Full-Time
  • Minimum Experience
    Entry-level
  • Compensation
    £20,000 - £28,000 per annum, dependent on experience plus benefits